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KMID : 0043320060290080627
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Archives of Pharmacal Research
2006 Volume.29 No. 8 p.627 ~ p.632
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Aporphine Alkaloids and their Reversal Activity of Multidrug Resistance (MDR) from the Stems and Rhizomes of Sinomenium acutum
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Min Yong-Deuk
Choi Sang-Un
Lee Kang-Ro
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Abstract
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Chromatographic separation of the MeOH extract from the stems and rhizomes of Sinomemium acutum led to the isolation of nine alkaloids and a lignan. Their structures were determined to be dauriporphine (1), bianfugecine (2), dauriporphinoline (3), menisporphine (4), (-)- syringaresinol (5), N-feruloyltyramine (6), acutumine (7), dauricumine (8), sinomenine (9), and magnoflorine (10) by spectroscopic means. These compounds were examined for their P-gp mediated MDR reversal activity in human cancer cells. Compound 1 showed the most potent P-gp MDR inhibition activity with an ED50 value 0.03 μg/mL and 0.00010 μg/mL in the MESSA/ DX5 and HCT15 cells, respectively.
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KEYWORD
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Sinomenium acutum, Menispermaceae, MDR, Aporphine alkaloid, Lignan
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